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用组化方法与Ｎｏｒｔｈｅｒｎ分子杂交技术分析测定了增龄鼠肌纤维横截面积（ＣＡＳ）与肌凝蛋白重链ⅡＢ型蛋白的基因表达和运动后上述两个指标的变化。结果显示：增龄鼠肌纤维横截面积减小，表现出肌萎缩的特征。同时，肌凝蛋白重链ⅡＢ型蛋白的基因表达水平下降。运动后肌纤维横截面积增大，同时肌凝蛋白重链ⅡＢ型蛋白的基因表达水平升高。提示增龄骨骼肌萎缩的发生与其增龄后肌纤维蛋白的基因表达水平下降使肌纤维蛋白合成能力下降，导致肌肉萎缩。运动可以提高肌纤维蛋白的基因表达水平，来增加肌纤维的蛋白合成能力，增大ＣＡＳ，从而减轻机体增龄或衰老后肌肉的萎缩程度。
Histochemistry and Northern blot were used to analyze the gene expression of myofibrillar cross-sectional area (CAS) and myosin heavy chain type IIB protein and the change of these two indexes after exercise. The results showed that: Aging mice muscle fiber cross-sectional area decreases, showing the characteristics of muscle atrophy. At the same time, myosin heavy chain type IIB protein gene expression decreased. After exercise, the cross-sectional area of myofibers increases, and the gene expression level of myosin heavy chain type IIB protein increases. Tip of aging skeletal muscle atrophy and its aging after the decline in the expression of myofibrillar genes decreased muscle fiber protein synthesis, resulting in muscle atrophy. Exercise can increase the level of muscle fiber protein gene expression, to increase muscle fiber protein synthesis capacity, increase CAS, thereby reducing body aging or aging muscle atrophy.