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目的探讨宫颈癌患者促性腺激素释放激素(GnRH)阳性蛋白表达及其临床意义。方法选取2014年8月-2016年8月在该院接受治疗的110例宫颈癌患者的临床资料作为宫颈癌组;选取同期110例慢性宫颈炎患者的临床资料作为慢性宫颈炎组。观察两组患者GnRH蛋白阳性表达率,比较不同临床病理特征宫颈癌患者GnRH蛋白阳性表达率的差异,分析影响宫颈癌患者GnRH蛋白阳性表达率的因素。结果宫颈癌组患者宫颈组织中的GnRH蛋白阳性表达率明显高于慢性宫颈炎组(χ~2=130.725,P<0.001);临床分期为Ⅲ期、中低分化、有浸润和转移的宫颈癌患者宫颈组织中GnRH蛋白阳性表达率较高,而不同年龄患者GnRH蛋白阳性表达率比较差异无统计学意义(P>0.05);将单因素分析有意义的因素作为自变量,以GnRH蛋白阳性表达率作为因变量,进行Logistic回归分析。结果显示临床分期和组织学分级是宫颈癌患者GnRH蛋白阳性表达的影响因素(OR=4.895、5.112,P<0.05)。结论宫颈癌患者的GnRH蛋白阳性表达率较高,与患者的临床分期和组织学分级密切相关。
Objective To investigate the expression of gonadotropin-releasing hormone (GnRH) positive protein in patients with cervical cancer and its clinical significance. Methods The clinical data of 110 cases of cervical cancer treated in our hospital from August 2014 to August 2016 were selected as the cervical cancer group. The clinical data of 110 cases of chronic cervicitis in the same period were selected as the chronic cervicitis group. The positive rate of GnRH protein expression in both groups was observed. The difference of GnRH protein expression in cervical cancer patients with different clinicopathological features was analyzed. The factors affecting the expression of GnRH protein in cervical cancer patients were analyzed. Results The positive rate of GnRH protein in cervical cancer patients was significantly higher than that in chronic cervicitis patients (χ ~ 2 = 130.725, P <0.001). The clinical stage was stage Ⅲ, moderately poorly differentiated, with invasive and metastatic cervical cancer The positive rate of GnRH protein expression in cervical tissues was higher than that of GnRH protein in different age groups (P> 0.05). The univariate analysis of the significance of factors as an independent variable to GnRH protein expression Logistic regression analysis was used as the dependent variable. The results showed that clinical stage and histological grade were the influential factors of GnRH protein expression in patients with cervical cancer (OR = 4.895,5.112, P <0.05). Conclusion The positive rate of GnRH protein in cervical cancer patients is high, which is closely related to the clinical stage and histological grade.