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目的 :观察甘露醇对降低人工晶体植入术后并发症的临床效果。方法 :将 52 6例、6 18眼人工晶体植入术随机分为A、B 2组 ,A组为甘露醇治疗组 ,B组为对照组用醋氮酰胺治疗 ,分别对 2组患者的术后眼压、前房反应、后囊混浊等进行观察分析。结果 :术后 72h内 2组患者高眼压的发生率差异无显著性 (P >0 0 5) ,而间断性低眼压的发生率A组高于B组 ,差异有高度显著性 (P <0 0 1)。A组中 6、2 4、4 8h眼压为甘露醇用药 2h内的眼压 ,其眼压平均值均低于B组同一时间的眼压平均值 ,差异有显著性 (P <0 0 1,P <0 0 5)。前房反应A组的发生率低于B组 ,平均随访 15 7个月 ,后囊混浊的发生率 ,A组低于B组 ,差异有高度显著性 (P <0 0 1)。结论 :甘露醇用于人工晶体植入术后 ,不仅有预防术后高眼压的作用 ,而且对促进前房反应的消退 ,降低后囊混浊的发生有明显效果。
Objective: To observe the clinical effect of mannitol in reducing complications after intraocular lens implantation. Methods: 526 cases and 618 eyes were randomly divided into group A and group B. Group A was treated with mannitol, while group B was treated with acetazolamide. Patients in two groups IOP, anterior chamber reaction, posterior capsule opacity were observed and analyzed. Results: There was no significant difference in the incidence of intraocular hypertension between the two groups within 72 hours after surgery (P> 0.05), while the incidence of intermittent hypotensive hypertension in group A was higher than that in group B (P> 0.05). The difference was significant <0 0 1). In group A, intraocular pressure of 6,2,4,4 8 hours was intraocular pressure within 2 hours of mannitol administration, the average intraocular pressure of group A was lower than the average intraocular pressure at the same time of group B, the difference was significant (P <0.01 , P <0 0 5). The incidence of anterior chamber reaction in group A was lower than that in group B, with an average follow-up of 15 7 months. The incidence of posterior capsule opacification was lower in group A than in group B, the difference was highly significant (P <0.01). Conclusion: Mannitol used for intraocular lens implantation not only has the effect of preventing postoperative intraocular hypertension, but also has obvious effect on promoting the regression of anterior chamber reaction and reducing the incidence of posterior capsule opacification.