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目的 揭示长春市老龄人群中前列腺癌的发病现状 ,探讨PSA在前列腺癌人群筛查及对临床分期预测中的意义。以长春市 12 0 2 7名 5 5岁以上男性为对象。EIA技术测定血清前列腺特异抗原 (PSA) :以PSA >4 .0ng/ml者确定为前列腺癌可疑病例 ,经直肠行超声引导下前列腺 6点活检 ,病理学诊断 ;参照国际标准进行ABCD和TNM临床分期 ,并分析血清PSA含量与临床分期的相关关系。结果 表明 :①血清PSA >4 .0ng/ml者占6 .8% (813/ 12 0 7) ,针对总体癌发现率为 0 .5 7% (6 9/ 12 0 2 7) ;②前列腺癌的ABCD和TNM分期显示未突破被膜的A、B期和T1、T2期分别为 5 8.8%和 5 9.6 % ,而发生淋巴结和远位转移的晚期前列腺癌均超过 2 0 % ;③与相关分析表明ABCD、TNM分期与PSA含量间均呈明显的正相关关系。结论 血清PSA含量不仅是前列腺癌人群筛查的金指标 ,而且 ,可预测前列腺癌的临床分期 ;证明在老龄人群中确有无症状的早、中和晚期前列腺癌患者 ,提示前列腺癌集团检诊的重要性
Objective To reveal the incidence of prostate cancer in the elderly population in Changchun and to explore the significance of PSA in the screening of prostate cancer population and clinical stage prediction. A total of 12 027 males over 5 years old in Changchun were enrolled. EIA technology serum PSA: PSA> 4.0ng / ml identified as suspected cases of prostate cancer, transrectal ultrasound-guided prostate biopsy 6, pathological diagnosis; refer to international standards ABCD and TNM clinical Staging, and analysis of serum PSA content and clinical stage of the correlation. The results showed that: (1) Serum PSA> 4.0ng / ml accounted for 6.8% (813/127), the overall cancer detection rate was 0.57% (69/12 027); (2) Prostate cancer The ABCD and TNM stages showed no breakthrough in the A, B and T1, T2 and T2 stages were 58.8% and 59.6%, respectively, while the incidence of advanced prostate cancer with lymph node and distant metastasis were more than 20%; ③ Correlation analysis It showed that ABCD, TNM staging and PSA content showed a significant positive correlation between. Conclusions Serum PSA level is not only a gold index for prostate cancer screening but also predicts the clinical staging of prostate cancer. It is suggested that prostate cancer patients with early, middle and advanced stages of asymptomatic age in elderly population may be diagnosed with prostate cancer The importance of