复发性阿弗他溃疡(recurrent aphthous ulcer,RAU),又称复发性阿弗他口炎(recurrent aphthous stomatitis,RAS)、复发性口腔溃疡(recurrent oral ulcer,ROU),是一种很常见的口腔黏膜疾病[1,2],但是其发病机制还不是很明确[3,4]。近年来,一些学者认为机体免疫功能异常是该病的重要发病机制[5~7],RAU患者存在细胞功能下降以及T细胞亚群失调等状况。而细胞因子作为重要的传递介质,在细胞 Recurrent aphthous ulcer (RAU), also known as recurrent aphthous stomatitis (RAS), recurrent oral ulcer (ROU), is a common oral Mucosal disease [1,2], but the pathogenesis is not yet clear [3,4]. In recent years, some scholars believe that abnormal immune function of the body is an important pathogenesis of the disease [5-7], RAU patients with decreased cellular function and T cell subsets disorders and other conditions. While cytokines act as important mediators of transmission in cells