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目的探讨支气管肺泡灌洗液(BALF)中肿瘤相关物质群(TSGF)和铁蛋白(SF)对肺癌的早期诊断价值。方法纳入襄阳市中心医院胸外科及呼吸科2008年至2013年收治的50例肺癌和50例肺良性疾病患者。检测患者支气管肺泡灌洗液和血清中TSGF与SF的含量。结果肺癌患者血清TSGF[(73.29±14.29)U/mL比(54.01±8.18)U/mL,P<0.05]、SF[(265.02±47.60)μg/L比(97.92±21.89)μg/L,P<0.05]显著高于肺良性疾病患者。肺癌患者BALF中TSGF[(142.67±72.88)U/mL比(83.01±48.06)U/mL,P<0.05]、SF[(365.02±49.06)μg/L比(98.10±21.44)μg/L,P<0.05]显著高于肺良性疾病患者。肺癌患者BALF中TSGF、SF水平显著高于血清中的水平(P<0.05)。结论 BALF中TSGF和SF的测定对早期肺癌的诊断有一定价值,其临床价值优于血清。
Objective To investigate the early diagnostic value of TSGF and SF in bronchoalveolar lavage fluid (BALF). Methods Fifty cases of lung cancer and 50 cases of benign lung diseases were admitted to the department of thoracic surgery and respiratory department of Xiangyang Central Hospital from 2008 to 2013. The contents of TSGF and SF in bronchoalveolar lavage fluid and serum were detected. Results Serum levels of TSGF were significantly higher in patients with lung cancer (73.29 ± 14.29 U / mL vs 54.01 ± 8.18 U / mL, P <0.05), SF [(265.02 ± 47.60) μg / L vs 97.92 ± 21.89 μg / L, <0.05] was significantly higher than in patients with benign lung disease. TSGF [(142.67 ± 72.88) U / mL vs 83.01 ± 48.06 U / mL, SF [(365.02 ± 49.06) μg / L, P <0.05] was significantly higher than in patients with benign lung disease. The levels of TSGF and SF in BALF of lung cancer patients were significantly higher than those in serum (P <0.05). Conclusion The determination of TSGF and SF in BALF has some value in the diagnosis of early stage lung cancer, and its clinical value is better than that of serum.