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目的观察奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血的临床效果。方法选取2015年7月-2016年7月医院接收治疗的胃溃疡合并胃出血患者100例,按照不同用药方法划分成研究组和对照组各50例。对照组实施奥美拉唑治疗,研究组实施奥美拉唑联合铝碳酸镁治疗,比较2组患者临床效果、临床症状评分、临床症状改善时间、住院时间及不良反应情况,包括恶心呕吐、失眠、四肢乏力、口干。结果研究组总有效率94.0%高于对照组的72.0%,差异有统计学意义(χ~2=5.47,P<0.05)。研究组临床症状评分低于对照组,临床症状改善时间及住院时间均短于对照组,差异均有统计学意义(P<0.05)。研究组出现恶心呕吐1例、四肢乏力1例、口干1例;对照组出现恶心呕吐2例、失眠3例、四肢乏力2例、口干2例;研究组不良反应发生率为6.0%低于对照组的18.0%,差异有统计学意义(P<0.05)。结论奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血临床效果可观,具备临床推广价值。
Objective To observe the clinical effects of omeprazole and magnesium aluminum carbonate in the treatment of gastric ulcer combined with gastric hemorrhage. Methods From July 2015 to July 2016, 100 patients with gastric ulcer and gastric hemorrhage who received treatment in our hospital were divided into study group and control group according to different medication methods. The control group was treated with omeprazole. The study group was treated with omeprazole combined with aluminum magnesium carbonate. The clinical effect, clinical symptom score, clinical symptom improvement time, hospitalization time and adverse reactions were compared between the two groups, including nausea and vomiting, insomnia Extremities weakness, dry mouth. Results The total effective rate 94.0% in the study group was higher than that in the control group 72.0%, the difference was statistically significant (χ ~ 2 = 5.47, P <0.05). The scores of clinical symptoms in the study group were lower than those in the control group, and the improvement of clinical symptoms and hospital stay were shorter than that of the control group (P <0.05). The study group showed nausea and vomiting in 1 case, weakness in limbs in 1 case and dry mouth in 1 case. The control group showed nausea and vomiting in 2 cases, insomnia in 3 cases, limb weakness in 2 cases and dry mouth in 2 cases. The adverse reaction rate in study group was 6.0% 18.0% of the control group, the difference was statistically significant (P <0.05). Conclusion Omeprazole combined with hydrotalcite in the treatment of gastric ulcer combined with gastric bleeding has a significant clinical effect, with clinical value.