最近研究显示,CT测量支气管壁增厚是气道重构的一个标志,与成人肺功能相关。法国研究人员使用高分辨CT测量了37例严重哮喘儿童的支气管壁厚度, 以判断支气管增厚是否与支气管炎症标志物和重建有关。结果显示,支气管壁厚度积分值与肺功能测定结果无关,也与支气管肺泡灌洗液中γ-干扰素、白介素-4和白介素-5水平无关。但其厚度积分与气道壁最大一氧化氮(NO)流量有关,与肺泡NO浓度无关。 Recent studies have shown that CT measurement of bronchial wall thickening is a hallmark of airway remodeling and is associated with adult lung function. French researchers measured the bronchial wall thickness in 37 children with severe asthma using high resolution CT to determine whether bronchial thickening is associated with bronchial inflammation markers and reconstruction. The results showed that the integral value of bronchial wall thickness had nothing to do with the results of pulmonary function test, but also had no correlation with the level of IFN-γ, IL-4 and IL-5 in bronchoalveolar lavage fluid. However, its thickness integral was related to the maximal nitric oxide (NO) flow in the airway wall, regardless of the alveolar NO concentration.