应用脐带动脉修复鼓膜穿孔,早在六十年代就有报道。因其制备繁杂,宽度有限,只能修复中、小鼓膜穿孔,故未能推广使用。1980年吴润身对其制备方法进行了改进,不仅加大了宽度,能修复大穿孔,而且可一次制备多次使用,经临床应用,证明其确是一种有价值的材料。然而,对其修复鼓膜穿孔后的组织病理变化研究,国内尚未见报道,因此,特进行了动物实验。材料和方法取400克左右体重的豚鼠6只(雌雄均可),在腹腔注射25％乌拉坦1毫升,加乙醚间断吸入麻醉后,于10倍手术显微镜下操作,将右耳鼓膜作为脐带动脉修复侧,左耳 The use of umbilical artery repair tympanic membrane perforation, as early as the sixties have been reported. Because of its preparation complex, limited width, only repair, the tympanic membrane perforation, it failed to promote the use of. In 1980, Wu Run improved its preparation method, not only increased the width, can repair large perforation, and can be prepared for multiple uses once. The clinical application proves that it is indeed a valuable material. However, the repair of tympanic membrane perforation after histopathological changes, has not been reported in the country, therefore, in particular, animal experiments. Materials and Methods 6 guinea pigs with body weight of about 400 g (both male and female) were inoculated intraperitoneally with 1 ml of 25% urethane and anesthetized with intermittent inhalation of ethyl ether. Under a 10-times operating microscope, the right eardrum was used as umbilical artery Repair side, left ear