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目的:研究大黄素对肝纤维化大鼠血清透明质酸的影响。方法:采用40％四氯化碳(CCl_4)给大鼠皮下注射制备肝纤维化模型,并以小、中和大剂量大黄素治疗,通过放射免疫法测定大鼠血清透明质酸。结果:大黄素组血清透明质酸显著低于模型组。结论:大黄素能降低肝纤维化大鼠血清透明质酸。
Objective: To study the effect of emodin on serum hyaluronic acid in liver fibrosis rats. METHODS: Rat models of hepatic fibrosis were prepared by subcutaneous injection of 40% carbon tetrachloride (CCl_4) and treated with small, medium, and high doses of emodin. Rat serum hyaluronic acid was measured by radioimmunoassay. Results: Serum hyaluronic acid was significantly lower in the emodin group than in the model group. Conclusion: Emodin can reduce serum hyaluronic acid in liver fibrosis rats.