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目的了解糖尿病足部溃疡全身综合治疗的同时结合溃疡局部外敷黄芪提取液的临床效果。方法在全身系统综合治疗的基础上,以生理盐水加胰岛素(对照组)作对照,观察黄芪提取液加适量胰岛素(治疗组)持续外敷后肉芽初现时间(GT),溃疡愈合时间(HT),截肢(趾)率和死亡率的高低。结果①治疗组相应的GT和HT均显著短于对照组(均P<0.05);②75例治疗组患者中截肢(趾)者9例,占12.0%,死亡2例,占2.7%;对照组67患者中截肢或趾者25例,占37.3%,死亡7例,占10.4%,两组间截肢率存在有显著差异(P<0.05)。结论黄芪提取液外敷对糖尿病足部溃疡有治疗效果,可显著缩短溃疡愈合时间,减低截肢率。
Objective To understand the clinical effect of combined external application of Astragalus extract on ulcer ulcer combined with systemic treatment of diabetic foot ulcer. Methods Based on general systemic therapy, saline and insulin (control group) were used as controls to observe the initial time of granulation (GT), the healing time of ulcer (HT) and the time course of external application of astragalus extract plus appropriate amount of insulin , Amputation (toe) rate and the level of mortality. Results ① The corresponding GT and HT in the treatment group were significantly shorter than those in the control group (all P <0.05). ② Among the 75 patients in the treatment group, 9 were amputated (12.0%) and 2 died (2.7%), while those in the control group Among the 67 patients, 25 cases were amputation or toe, accounting for 37.3%, and 7 died, accounting for 10.4%. The amputation rate was significantly different between the two groups (P <0.05). Conclusion External application of Astragalus extract on diabetic foot ulcers have a therapeutic effect, can significantly reduce the ulcer healing time, reduce the amputation rate.