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报告口服巯甲丙脯酸并用硝苯吡啶治疗40例原发性高血压病,观察6周,降压有效率与显效率分别为97.5%与87.5%,症状改善率为90%左右。未发现与脂质代谢、糖代谢、尿酸代谢、肾功能及肝脏功能的不良影响,提示心功能有改善作用。治疗前测定血浆心钠素浓度降低,与国内文献报告一致,治疗后血浆心钠素浓度升高,可能与巯甲丙脯酸抑制其降解有关。本组疗效与肾素分型之间无显著差异,有利于作为非选择性第一线用药。
Reported oral captopril and nifedipine treatment of 40 cases of essential hypertension, observation of 6 weeks, the effective rate of antihypertensive and markedly effective rate was 97.5% and 87.5%, 90% improvement rate of symptoms. No adverse effects were found with lipid metabolism, glucose metabolism, uric acid metabolism, renal function and liver function, suggesting that cardiac function may be improved. Determination of plasma atrial natriuretic peptide before treatment decreased, consistent with the domestic literature, plasma atrial natriuretic peptide concentration after treatment may be related to the inhibition of the degradation of captopril. No significant difference between the efficacy of this group and renin type, is conducive to the first choice as a non-selective drug.