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目的：探索牛磺酸对应激性心肌损伤的保护机理。方法：以异丙肾上腺素（ＩＳＯ）诱导的大鼠应激为模型，测定应激大鼠血清和心肌中Ｔ３、Ｔ４水平及心肌与肝脏中Ｔ４５－脱单碘酶（Ｔ４５－ＤＩ）活性的变化。结果：ＩＳＯ组大鼠血清、心肌中Ｔ３水平及心肌与肝脏中Ｔ４５－ＤＩ活性显著高于对照组，Ｔ４水平显著低于对照组；而牛磺酸组除血清中Ｔ３和心肌中Ｔ４５－ＤＩ活性显著高于对照组、低于ＩＳＯ组外，血清中Ｔ４和心肌中Ｔ３、Ｔ４水平及肝脏中Ｔ４５－ＤＩ活性与对照组未见显著差异。结论：牛磺酸可通过纠正应激大鼠甲状腺激素代谢亢进来减轻Ｔ３过量所致心肌能源耗竭，保护心肌免受应激损伤。
Objective: To explore the protective mechanism of taurine on stress myocardial injury. Methods: The rat stress induced by isoproterenol (ISO) was used as a model to measure the level of T3 and T4 in serum and myocardium of stress rats and the level of T45-deiodinase (T45-DI) in myocardium and liver. Changes in activity. Results: The level of T3 in myocardium and myocardium and the activity of T45-DI in myocardium and liver in ISO group were significantly higher than those in control group, while the level of T4 in T4 group was significantly lower than that in control group. In taurine group, T3 in serum and T45 in myocardium -DI activity was significantly higher than the control group, lower than the ISO group, serum T4 and myocardial T3, T4 levels and T45-DI activity in the liver and the control group showed no significant difference. CONCLUSION: Taurine can relieve myocardial energy exhaustion caused by T3 excess and protect myocardium from stress damage by correcting hyperthyroidism of thyroid hormone in stress rats.