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本实验分为体内体外两部分。体内实验证明芦笋对由肌氨酸乙酯亚硝胺诱发的小鼠前胃鳞状上皮癌变具有明显的抑制作用,对照组癌变率为63.0％,芦笋组为26.8％,两组癌变率与胃重比较在统计学上均有显著差异(P<0.01);形态学观察显示,芦笋不但可以降低癌变率而且可以阻止癌细胞的浸润。体外,芦笋对3T3细胞的生长曲线与分裂指数均有一定的抑制作用,细胞增殖缓慢,但无明显毒性。本文还讨论了芦笋抑制癌变的可能机理。
This experiment is divided into two parts: in vitro and in vivo. In vivo experiments demonstrated that asparagus had a significant inhibitory effect on squamous epithelial carcinogenesis in mice induced by sarcosine ethyl ester nitrosamines. The rate of canceration was 63.0% in the control group and 26.8% in the asparagus group. The rate of canceration in both groups was comparable to that in the stomach. There was a statistically significant difference in weight comparison (P<0.01); morphological observations showed that asparagus can not only reduce the cancer rate but also can prevent cancer cell infiltration. In vitro, asparagus had a certain inhibition on the growth curve and mitotic index of 3T3 cells. The proliferation of cells was slow, but there was no obvious toxicity. This paper also discusses the possible mechanism of asparagus inhibiting canceration.