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人类在公元前2000年就有了用加温治疗肿瘤的记录。Hippocraates(公元前400年)和Galen(公元200年)用烧红的铁块置于体表肿瘤上,使肿瘤缩小。1898年F.W-estmark 制作了热循环水箱治疗子宫癌,本世纪初德国人Arsonval,Telsa 报告用高频电流局部治疗肿瘤并获得疗效。1926年Na-gelshmidt 提出了“热透深”的术语,1927年N.Westermark 提出剂量/时间反应概念及加热效果的组织病理学评价。1962年Cri-le 报告了对人及狗的自发肿瘤用微波加热与放射的综合治疗可以达到局部控制。1967年Cavalieve 报告与正常细胞相比肿瘤细胞对热更敏感,适宜温度为42°～45℃(108℉～
Humans had a record of using warming to treat tumors in 2000 BC. Hippocraates (400 BC) and Galen (200 AD) used red-hot iron masses on surface tumors to shrink tumors. In 1898, F.W-estmark produced a thermal circulating tank for the treatment of uterine cancer. At the beginning of this century, German Arsonval, Telsa reported using local high-frequency currents to treat tumors and obtain therapeutic effects. In 1926 Na-gelshmidt proposed the term “heat penetration”, and in 1927 N. Westermark proposed the dose/time response concept and histopathological evaluation of the heating effect. In 1962 Cri-le reported that the combined treatment of microwave and radiation for spontaneous tumors in humans and dogs can achieve local control. In 1967, Cavalieve reported that tumor cells are more sensitive to heat than normal cells, and the suitable temperature is 42° to 45°C (108°F～