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目的探讨β3AR基因多态性与高血糖人群膳食干预效果的关系,为糖尿病的膳食干预提供遗传学依据。方法从南京市8个社区抽取233名汉族高血糖者,随机分为复合干预组(154人)和对照组(79人)。干预组给予粗粮干预和进行健康进座,对照组不采取任何措施,试验周期6个月。结果干预组Trp/Trp基因型者体质指数(BMI)、腰臀比(WHR)、舒张压(DBP)、空腹血糖(FBG)、血总胆固醇(TC)水平明显降低,高密度脂蛋白胆固醇(HDLC)水平明显上升(P<0.05);Trp/Arg基因型组BMI、WHR、FBG水平明显降低,HDLC水平明显上升(P<0.05)。Arg/Arg基因型组无明显变化。此外,Trp/Trp型人群的BMI、WHR和FBG下降的干预效果明显大于Trp64Arg型和Arg/Arg型,而Trp64Arg型人群的这3项指标下降又明显大于Arg/Arg型(P<0.05)。结论高血糖人群膳食干预效果因β3AR基因型不同而有差异,其中,Trp/Trp人群对膳食干预效果最佳,Trp/Arg次之,而Arg/Arg效果较差。
Objective To investigate the relationship between β3AR gene polymorphism and dietary intervention in hyperglycemic subjects and to provide a genetic basis for dietary intervention in diabetes mellitus. Methods A total of 233 Han Chinese hyperglycemic individuals from 8 communities in Nanjing were randomly divided into the intervention group (154) and the control group (79). Intervention group to give coarse grain intervention and health into the seat, the control group did not take any measures, the test period of 6 months. Results The body mass index (BMI), WHR, DBP, FBG and TC in the intervention group were significantly lower than those in the control group. The levels of high density lipoprotein cholesterol (P <0.05). The levels of BMI, WHR and FBG in the Trp / Arg genotype were significantly decreased (P <0.05), and HDLC levels were significantly increased (P <0.05). Arg / Arg genotype group no significant change. In addition, the effects of decreasing BMI, WHR and FBG in Trp / Trp population were significantly greater than those in Trp64Arg and Arg / Arg population, while those in Trp64Arg population were significantly lower than those in Arg / Arg group (P <0.05). Conclusion The effect of dietary intervention in hyperglycemic patients varies with the type of β3AR. Among them, Trp / Trp has the best dietary intervention, Trp / Arg followed by Arg / Arg.