共调节因子与受体的相互作用在核受体介导的信号转导途径中极为关键,因此阻断两者的结合,可以作为治疗肿瘤的方案之一。雄激素受体(AR)是前列腺癌细胞生长过程中一个重要的调节因子,属于核受体超家族的一员,也是受配体调节的转录因子。无配体存在时AR无转录激活活性;配体的结合 Co-regulatory factors and receptor interactions in the nuclear receptor-mediated signal transduction pathway is critical, thus blocking the combination of the two, as one of the programs to treat cancer. Androgen receptor (AR) is an important regulatory factor in the growth of prostate cancer cells. It belongs to the nuclear receptor superfamily and is also a ligand-regulated transcription factor. AR without transcriptional activation in the absence of ligand; ligand binding