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目的：探讨血管紧张素Ⅱ受体－１（ＡＴ１受体）在清醒ＷＫＹ大鼠和自发性高血压大鼠（ＳＨＲ）血压波动性（ＢＰＶ）调节中的作用。方法：应用计算机化清醒自由活动大鼠血流动力学监测技术，分别观察了：（１）静注新型非肽类ＡＴ１受体拮抗剂Ｌｏｓａｒｔａｎ（Ｌｏｓ）；（２）静注神经节阻断剂氯异吲哚铵（Ｃｈｌｏｒ）；（３）静注Ｃｈｌｏｒ和Ｌｏｓ；（４）静滴血管紧张素Ⅱ（ＡＮＧⅡ）及静注Ｃｈｌｏｒ后静滴ＡＮＧⅡ对ＷＫＹ大鼠和ＳＨＲ血压和ＢＰＶ的影响。结果：Ｌｏｓ不影响ＷＫＹ大鼠的血压，但减小其ＢＰＶ，降低ＳＨＲ的血压，但不影响其ＢＰＶ。Ｃｈｌｏｒ降低ＷＫＹ大鼠和ＳＨＲ的血压，增大它们的ＢＰＶ。Ｃｈｌｏｒ＋Ｌｏｓ可降低ＷＫＹ大鼠和ＳＨＲ的血压，但不影响它们的ＢＰＶ。静滴ＡＮＧⅡ升高ＷＫＹ大鼠和ＳＨＲ的血压，增大它们的ＢＰＶ；静注Ｃｈｌｏｒ后再静滴ＡＮＧⅡ，两者血压均维持在各自基础值水平，而ＢＰＶ都极显著增大。结论：交感神经调节的介入掩盖了Ｌｏｓ对ＳＨＲＢＰＶ的影响；交感神经被阻断后，ＡＴ１受体的激活不仅对血压的维持有代偿作用，而且与此时血压发生剧烈波动，即ＢＰＶ增大有关。
AIM: To investigate the role of angiotensin Ⅱ receptor-1 (AT1 receptor) in the regulation of blood pressure variability (BPV) in conscious WKY rats and spontaneously hypertensive rats (SHR). Methods: The computerized conscious free-moving hemodynamic monitoring technique was used to observe the effects of intravenous injection of Losartan (Los), a novel non-peptide AT1 receptor antagonist, (2) intravenous ganglioside blocker (3) intravenous injection of Chlor and Los; (4) intravenous infusion of angiotensin Ⅱ (ANG Ⅱ) and intravenous infusion of ANG Ⅱ on WKY rats and SHR blood pressure and BPV. Results: Los did not affect the blood pressure of WKY rats, but decreased BPV and decreased the blood pressure of SHR, but did not affect BPV. Chlor reduces blood pressure in WKY rats and SHRs and increases their BPV. Chlor + Los reduces blood pressure in WKY rats and SHR but does not affect their BPV. Angiotensin Ⅱ increased the blood pressure of WKY rats and SHR, and increased their BPV. After intravenous injection of Chlorine, intravenous infusion of AngⅡ was maintained. The blood pressure of both groups maintained at their respective baseline levels, while BPV increased significantly. CONCLUSIONS: The intervention of sympathetic regulation masks the effect of Los on SHRBPV. After the sympathetic nerve is blocked, the activation of AT1 receptor not only compensates for the maintenance of blood pressure, but also violently fluctuates with the increase of BPV related.