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目的观察选择性血浆净化器对胆红素吸附的疗效及安全性。方法选择慢性乙型肝炎重度、慢性重型乙型肝炎和药物性肝损害24例,在综合治疗基础上给予血浆灌流支持治疗,观察血浆灌流支持治疗前后肝功能、血常规、凝血三项、组织相容性评价及血气分析的变化情况,并记录不良反应的发生率。结果所有患者治疗后血清TBIL、DBIL、IBIL分别下降(105.49±33.10)、(55.63±24.22)、(49.83±26.79)μmol/L,经自身配对t检验,P均<0.05;治疗过程中患者耐受性好,无明显不良反应发生。结论选择性血浆净化器不仅有好的治疗效果,而且安全性好。
Objective To observe the curative effect and safety of selective plasma purifier on bilirubin adsorption. Methods Twenty-four patients with severe chronic hepatitis B and drug-induced liver damage were selected for the treatment of chronic hepatitis B and drug-induced liver damage. Plasma-perfusion therapy was given on the basis of comprehensive treatment. The changes of liver function, blood routine, coagulation, To assess the changes in the capacity and blood gas analysis, and record the incidence of adverse reactions. Results The serum levels of TBIL, DBIL and IBIL in all patients decreased (105.49 ± 33.10), (55.63 ± 24.22) and (49.83 ± 26.79) μmol / L, respectively, after paired t test By sex, no obvious adverse reactions. Conclusion Selective plasma purifier not only has good therapeutic effect, but also has good safety.