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检验结果的一致性由来已久且一直是检验界的目标。虽然已经取得了一些进步,但任有很多问题要解决。对于所有肿瘤标志物而言,因其检测缺乏一致性可能对肿瘤患者的诊疗产生严重的影响。本文将对这方面以往的努力与进步进行回顾,如参考物质方面所取得的一些检验结果一致性的重要文献。深入讨论前列腺特异性抗原(PSA)的第一个国际标准的发展及其对PSA检测的贡献。最后,本文应用作者自己实验室的1个实例来说明实现一致性为最终目标的可能性,即不同实验室在不同时间用不同方法检测得到一致检验结果。
The consistency of the test results has a long history and has always been the goal of the testing community. Although some progress has been made, there are many problems to be solved. For all tumor markers, the lack of consistency in their detection may have a serious impact on the diagnosis and treatment of cancer patients. This article reviews past efforts and advances in this area, such as some important references on consistency of test results with reference to materials. In-depth discussion of the development of the first international standard for prostate-specific antigen (PSA) and its contribution to PSA testing. Finally, we use an example of the author’s own laboratory to illustrate the possibility of achieving consistency as the ultimate goal, that is, different laboratories use different methods to test consistent test results at different times.