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目的探讨消栓肠溶胶囊治疗高血压性脑出血并发头痛的临床疗效。方法选取宜宾市第一人民医院2015年收治的高血压性脑出血并发头痛患者190例,按照随机数字表法分为对照组(n=100)和治疗组(n=90)。对照组患者给予非洛地平缓释片治疗,治疗组患者在对照组基础上给予消栓肠溶胶囊治疗,两组患者均持续治疗14 d。比较两组患者治疗前后头痛症状评分、临床疗效及治疗前后收缩压、舒张压,观察患者不良反应发生情况。结果治疗前,两组患者头痛评分比较,差异无统计学意义(P>0.05);治疗后,治疗组患者头痛评分低于对照组(P<0.05)。治疗组患者头痛治疗总有效率高于对照组(P<0.05)。治疗前,两组患者收缩压、舒张压水平比较,差异无统计学意义(P>0.05);治疗后,治疗组患者收缩压、舒张压水平低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用消栓肠溶胶囊治疗高血压性脑出血并发头痛的临床疗效明显,可有效缓解患者的头痛症状,且安全可靠。
Objective To investigate the clinical efficacy of Xiaoshuan enteric-coated capsules in the treatment of hypertensive cerebral hemorrhage complicated with headache. Methods Totally 190 hypertensive intracerebral hemorrhage patients with headache who were admitted to Yibin First People’s Hospital in 2015 were divided into control group (n = 100) and treatment group (n = 90) according to random number table. Patients in the control group were treated with sustained-release tablets of felodipine. Patients in the treatment group were treated with Xiaoshuan enteric-coated capsules on the basis of the control group, and both groups were treated for 14 days. The headache symptom score, clinical curative effect and systolic blood pressure and diastolic blood pressure before and after treatment were compared between the two groups before and after treatment. The incidence of adverse reactions was observed. Results Before treatment, there was no significant difference in headache scores between the two groups (P> 0.05). After treatment, headache score of the treatment group was lower than that of the control group (P <0.05). The total effective rate of headache treatment in treatment group was higher than that in control group (P <0.05). Before treatment, systolic blood pressure and diastolic blood pressure were not significantly different between the two groups (P> 0.05). After treatment, systolic blood pressure and diastolic blood pressure were lower in the treatment group than those in the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The clinical curative effect of relieving cerebral hemorrhage complicated with headache by using Xiaoet Chang enteric-coated capsule is obvious, which can effectively relieve headache symptoms of patients and is safe and reliable.