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目的探讨转录因子Sp1在乳腺癌中的表达及意义。方法采用免疫组化方法检测转录因子Sp1在53例乳腺浸润性导管癌2、5例导管内癌组织和13例乳腺囊性增生病组织中的表达。结果 Sp1在乳腺浸润性导癌、导管内癌及乳腺囊性增生组织中表达逐渐降低,有统计学意义。在浸润性导管癌中其表达与病理分级、脉管浸润和腋窝淋巴结转移显著相关。结论 Sp1与乳腺浸润性导管癌的发生、发展及淋巴结转移关系密切。
Objective To investigate the expression and significance of transcription factor Sp1 in breast cancer. Methods Immunohistochemistry was used to detect the expression of Sp1 in 53 cases of invasive ductal carcinoma of the breast, 2 cases of ductal carcinoma and 13 cases of cystic hyperplasia. Results The expression of Sp1 in infiltrating breast carcinoma, intraductal carcinoma and cystic mastocyst gradually decreased, with statistical significance. In invasive ductal carcinoma, its expression was significantly associated with pathological grade, vascular invasion and axillary lymph node metastasis. Conclusion Sp1 is closely related to the occurrence and development of breast invasive ductal carcinoma and lymph node metastasis.