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为进一步研究吸烟、高镉与尿石形成的关系,选用20只Wistar雄性大鼠,在膀胱内植入直径4mm的圆形金属锌片,后将动物随机分成实验组及对照组。两组均同时饮用1％乙二醇水,实验组每周吸烟5次,持续4周。实验前后测定大鼠24小时尿草酸、钙、磷、镉、β2-微球蛋白排泄量,用分级法评价结石形成及肾损伤程度,膀胱结石称其干重。结果显示吸烟组动物结石发生率高于对照组（P<0.01）,24小时尿草酸、钙、磷、镉和β2-微球蛋白排泄量显著高于实验前及对照组（P<0.01）,膀胱结石的体积、数目亦较对照组增加（P<0.01）。表明镉增高可促进泌尿系结石的形成。
To further study the relationship between smoking, high cadmium and urolith, 20 Wistar male rats were selected and 4 mm diameter round zinc metal sheets were implanted in the bladder. Animals were then randomly divided into experimental group and control group. Both groups also drink 1% ethylene glycol water, the experimental group smoked five times a week for 4 weeks. Urine oxalic acid, calcium, phosphorus, cadmium and β2-microglobulin excretion were measured in 24 hours before and after the experiment. Staging was used to evaluate the formation of stone and the degree of renal injury. Bladder calculus was called as dry weight. The results showed that the incidence of calculus in smoking group was higher than that in control group (P <0.01), and the urinary excretion of urinary oxalate, calcium, phosphorus, cadmium and β2-microglobulin in 24 hours were significantly higher than those in pre-treatment and control groups (P <0.01) The volume and number of bladder stones also increased compared with the control group (P <0.01). That cadmium can promote the formation of urinary stones.