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目的评估进展期胃癌患者新辅助化疗后手术的临床疗效。方法选择进展期胃癌患者48例分为常规手术组(24例)和新辅助化疗+手术组(24例),新辅助化疗+手术组患者进行2个周期的新辅助化疗,行CT复查,再进行手术治疗。结果常规手术组肿瘤切除率为83.3%,根治性切除率为45.8%,剖腹探查率为16.7%;新辅助化疗+手术组肿瘤切除率为91.7%,根治性切除率为62.5%,剖腹探查率为8.3%。两组均无手术死亡病例,并发症发生率差异无显著性。结论进展期胃癌患者在新辅助化疗后,进行手术治疗,可以提高手术根治率和切除率。
Objective To evaluate the clinical efficacy of neoadjuvant chemotherapy in patients with advanced gastric cancer. Methods Forty-eight patients with advanced gastric cancer were divided into two groups: conventional surgery group (n = 24) and neoadjuvant chemotherapy + surgery group (n = 24). Neoadjuvant chemotherapy plus surgery group received two cycles of neoadjuvant chemotherapy Surgical treatment. Results The tumor resection rate was 83.3%, the radical resection rate was 45.8% and the laparotomy rate was 16.7% in the conventional surgery group. The tumor resection rate was 91.7% in the neoadjuvant chemotherapy + operation group, and the radical resection rate was 62.5% 8.3%. No surgical deaths were found in both groups, with no significant difference in the incidence of complications. Conclusion In patients with advanced gastric cancer after neoadjuvant chemotherapy, surgical treatment can improve the cure rate and resection rate.