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多囊卵巢综合征(PCOS)至今病因不明,目前“产前雄激素过量”假说是PCOS病因研究热点。孕期高雄激素血症可致子代PCOS样表现型,但机制未明,研究处瓶颈阶段。高雄激素环境对子代生殖轴的影响,如卵巢内部结构改变、早期胰岛功能及其他代谢功能影响等的理论和研究结果亦存在争议或不足。通过对产前雄激素过量对雌性子代生殖轴和代谢影响最新研究进行综述,认为产前雄激素过量是PCOS病因之一,但具体作用机制有待进一步研究确定。
Polycystic ovary syndrome (PCOS) so far the etiology, the current “prenatal androgen excess” hypothesis is the cause of PCOS research hot spots. Hyperandrogenism during pregnancy can cause PCOS-like phenotype of offspring, but the mechanism is not clear, the research at the bottleneck stage. The effects of Kaohsiung Hormone on the reproductive axis of offspring, such as the internal structure of the ovary, the effects of early islet function and other metabolic functions, are also controversial or inadequate. The review of the latest research on the influence of prenatal androgen excess on the reproductive axis and metabolism of female offspring suggests that prenatal androgen excess is one of the causes of PCOS, but the specific mechanism of action needs to be further studied and confirmed.