偕二膦酸类化合物早已广泛应用于工业用水的软化、工业防锈等方面,但近期发现它对人体的矛齿等的矿化具有调节作用,可防龋齿、牙石等。所以对二膦酸存在下,生物矿化动力学的研究十分活跃。然而所有这些研究只以1-羟基-1,1-乙二膦酸(HEDP)为对象,显然存在局限性。为了探讨偕二膦酸的结构与生物矿化调节作用之间的关系,以期得到功效更好的结构,本文合成了一些衍生物。对于它们的生物矿化模型实验研究,将另文报道。 It has long been widely used in the softening of industrial water and industrial rust prevention. However, it has recently been found that it has a regulating effect on the mineralization of human’s spear teeth and the like, and can prevent dental caries, calculus and the like. So in the presence of bisphosphonic acid, the study of biomineralization kinetics is very active. However, all of these studies are targeted at 1-hydroxy-1,1-ethanediphosphonic acid (HEDP) only, with obvious limitations. In order to explore the relationship between the structure of the diphosphonic acid and the regulation of biomineralization, in order to obtain a more effective structure, some derivatives were synthesized in this paper. An experimental study of their biomineralization models will be reported separately.