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作者采用随机、双盲、非平衡、交叉、安慰以及对照方法,对比了H_2拮抗剂尼扎替丁(nizatidine)、西咪替丁和安慰剂对治疗高胃酸分泌疾病的效果。 6例高胃酸分泌男性受试者,在清晨7点和8点,给予本品75、150或300mg,下午5点予以假安慰剂或西咪替丁300mg,或在清晨7点、下午5点、8点予以安慰剂。采用Fordtran和Walsh方法测定标准蛋白食物刺激后的胃酸分泌。每3～5分钟采集胃内容物,测定其pH值。于清晨给药后0、0.5、1、2、3、4、6、8、10、12和24小时,采集血浆标本,于清晨给药后0～2、2～4、4～8、8～12、12～24小时,采集尿标本,分别测定血尿中
The authors compared the effects of the H 2 antagonists nizatidine, cimetidine, and placebo on patients with hypersecretory disorders using a randomized, double-blind, unbalanced, crossover, comfort, and placebo-controlled trial. 6 subjects with hypersecretion of acid were given 75, 150 or 300 mg of the product at 7 and 8 AM, and 300 mg or 5 mg of pseudo-placebo or cimetidine at 7:00 PM and 7:00 PM and 5:00 PM Placebo at 8 o’clock. Stomach acid secretion following standard protein diet stimulation was determined using the Fordtran and Walsh methods. Gastric contents were collected every 3 to 5 minutes and the pH was measured. Plasma samples were collected at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 hours after the early morning administration, ~ 12,12 ~ 24 hours, urine samples were collected, were measured in urine