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３８例具有疼痛症状的患者在合谷穴接受ＴＥＮＳ（穿皮电神经刺激）或电针治疗。将４２只小鼠分为６组：①度冷丁组，②颅痛定（阿片样中草药）组，③急性吗啡戒断（ＡＭＷ）组，④吗啡戒断加电针（ＭＷ＋ＥＡ）组，⑤ＭＷ无ＥＡ（ＭＷ－ＥＡ），⑥对照组。以钾离子透入法测痛阀。依ＡＮＡＥ－点型（Ｆ）或ＣＤ４淋巴细胞亚群检测细胞中介免疫（ＣＭＩ）。以免疫酶组织化学显示ｃＡＭＰ及ｃＧＭＰ免疫反应性（ＩＲ）。结果表明患者的ＴＥＮＳ镇痛及细胞中介免疫的效应均与ＥＡ的效应相似。小鼠的镇痛效应为吗啡＞度冷丁＞颅痛定＞电针或颅痛定，而细胞中介免疫的效应为ＥＡ＞颅痛定＞度冷丁或吗啡。ＡＭＷ组的小肠ｃＡＭＰ－ＩＲ增加而ｃＧＭＰ－ＩＲ相对减弱，ＥＡ能调控ｃＡＭＰ－ＩＲ及ｃＧＭＰ－ＩＲ趋向正常水平。
Thirty-eight patients with painful symptoms underwent TENS (electro-percutaneous electrical nerve stimulation) or electroacupuncture at Hoku. Forty-two mice were divided into 6 groups: ①Goldtin group, ②Rengtongding (opioid herbal) group, ③Acute morphine withdrawal group (AMW), ④Morphine withdrawal and electroacupuncture (MW + EA) group, EA (MW-EA), ⑥ control group. Potassium ion penetration method to measure pain valve. Cell mediated immunity (CMI) was measured by ANAE-spotting (F) or CD4 lymphocyte subsets. Enzymatic histochemistry shows cAMP and cGMP immunoreactivity (IR). The results showed that the effect of TENS analgesia and cell mediated immunity were similar to those of EA. The analgesic effect of mice was morphine> meperidine> cranialgia decoction> electroacupuncture or craniofacial syndrome, and the effect of cell mediated immunity was EA> craniofacial syndrome> meperidine or morphine. In the AMW group, the cAMP-IR increased and the cGMP-IR decreased. EA could regulate cAMP-IR and cGMP-IR to the normal level.