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目的评价干扰素联合LEEP术治疗宫颈上皮内瘤变的效果。方法将我院收治并确诊为宫颈上皮内瘤变(CIN)的患者随机分为观察组和对照组，对观察组患者应用干扰素联合LEEP术实施治疗，对对照组患者只行LEEP术进行治疗。观察两组患者的手术时间、术中出血量和创面愈合时间，同时观察两组患者在治疗前及治疗后3、6、9、12个月的TCT检查的异常率、HC2检测HPV的阴性率。结果两组患者手术时间、术中出血量的比较，差异无统计学意义(>0.05)；观察组的创面愈合时间短于对照组，差异有统计学意义(<0.05)；两组患者治疗前后自身比较中，患者的TCT检查异常率较治疗前明显下降，患者HC2检测HPV阴性率较治疗前明显上升，差异有统计学意义(<0.05)；两组患者治疗后3、6、9、12个月检查比较中，观察组的TCT检查的异常率均明显低于对照组，观察组的HC2检测HPV阴性率均明显高于对照组，差异有统计学意义(0.05);observation group wound healing time shorter than the control group,the dif erence had a statistical y meaning( <0.05);the two groups comparison of patients before and after treatment itself,the former TCT abnormalities rate than treatment of patients decreased significantly,it increased the detection of patients before HC2 HPV-negative rate than treatment,the dif erence had a statistical y meaning ( <0.05);the two groups of patients after treatment 3,6 compare 9,12 months inspection,observation group were significantly abnormal TCT check than the control group,the observation group HC2 HPV-negative detection rate was significantly higher,the dif erence had a statistical y meaning ( <0.05).Conclusion The treatment of interferon combined with LEEP surgery of patients with cervical intraepithelial neoplasia can not only accelerate wound healing in patients,but also ef ectively reduce the rate of abnormalities in patients with TCT and improve patient HC2 HPV-negative rate of detection has a significant ef ect.