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目的:研究家兔不同脑区神经元对全脑缺血再灌注损伤的敏感性。方法:结扎家兔左侧椎动脉,夹闭双侧颈总动脉40min,松开再灌流48h,72h。光镜观察。结果:神经元呈缺血性改变。海马、纹状体损伤严重,皮层病变轻微。结论:不同脑区神经元对缺血再灌流损伤的敏感性与其动脉分布有关。
Objective: To study the sensitivity of neurons in different brain regions to global cerebral ischemia-reperfusion injury in rabbits. Methods: The left vertebral artery was ligated in rabbits and the common carotid arteries were occluded for 40 minutes and reperfused for 48 hours and 72 hours respectively. Light microscope observation. Results: Neurons showed ischemic changes. Hippocampus, striatal damage, mild cortical lesions. Conclusion: The sensitivity of neurons in different brain regions to ischemia-reperfusion injury is related to their arterial distribution.