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目的探讨生长激素对人体衰老的影响。方法１２名自愿参加试验研究的健康老年人皮下注射人类生长激素（ｒ－ｈｕｍａｎｇｒｏｗｔｈｈｏｒｍｏｎｅ，ｒ－ｈＧＨ），剂量为０．０８Ｕ／ｋｇ，每周３次，共用６个月。结果胰岛素样生长因子（ｉｎｓｕｌｉｎ－ｌｉｋｅｇｒｏｗｔｈｆａｃｔｏｒ－１，ＩＧＦ－１）水平注射前均值为７６２±１７８Ｕ／Ｌ，注射３个月后升高为１０６２±１２７Ｕ／Ｌ，差异有显著性（Ｐ＜０．０１）。但注射６个月后，下降为６９７±１２４Ｕ／Ｌ，与３个月相比，差异亦有显著性（Ｐ＜０．０１）。ＩＧＦ－１下降原因不明。采用双能Ｘ线吸收仪（ｄｕａｌｅｎｅｒｇｙＸ－ｒａｙａｂｓｏｒｐｔｉｏｍｅｔｒｙ，ＤＥＸＡ）测定脂肪和精肉，试验前后分别为１４５５９±４１８２ｇ及１３７０９±３３２５ｇ和４９６８３±２８０及５０３１７±２９３５ｇ，但差异无显著性；骨密度在试验前后变化不显著。结论所有受试者试后均保持健康，除２例６个月血糖稍升高（分别从５．０８上升至７．８９ｍｍｏｌ／Ｌ和５．６７上升至８．２４ｍｍｏｌ／Ｌ）外，无明显副作用，对应用ｒ－ｈＧＨ延迟生理衰老的利弊尚需做更多病例观察。
Objective To investigate the effect of growth hormone on human aging. Methods 12 healthy volunteers, who volunteered to participate in the pilot study, were injected subcutaneously with human growth hormone (r-hGH) at a dose of 0.08U / kg three times a week for 6 months. Results The level of insulin-like growth factor-1 (IGF-1) was 762 ± 178 U / L before injection and rose to 1062 ± 127 U / L after 3 months of injection. The difference was significant (P <0. 01). However, after 6 months of injection, the decrease was 697 ± 124 U / L, which was also significantly different from 3 months (P <0.01). The cause of IGF-1 decline is unknown. Fat and meat were measured by dualenergy X-ray absorptiometry (DEXA). Before and after the test, the levels of 14559 ± 4182g, 13709 ± 3325g, 49683 ± 280 and 50317 ± 2935g were respectively determined, but the difference was not significant. No significant change. Conclusions All subjects remained healthy after the trial, with no significant difference except for 2 patients with slightly elevated blood glucose at 6 months (increased from 5.08 to 7.89 mmol / L and 5.67 to 8.24 mmol / L, respectively) Side effects, the application of r-hGH delay physiological aging, the advantages and disadvantages still need to do more case observations.