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目的观察高血糖、高血压患者中肾素-血管紧张素-醛固酮(renin-angiotensin-aldosterone,RAA)水平,探讨是否RAAS的激活是2者共同的发病机制。方法用放射免疫分析法测定106例正常人、112例单纯糖代谢异常患者、101例单纯原发性高血压患者及127例糖代谢异常合并原发性高血压患者的血浆RAA水平和活性。结果3组醛固酮水平均明显高于CON组,差异有统计学意义(P<0.01),I-IGM常组中血管紧张素Ⅱ水平明显高于其他各组,差异有统计学意义(P<0.01),各组间肾素活性差异无统计学意义。血浆醛固酮水平与空腹血糖、肾素、收缩压、血管紧张素Ⅱ高度相关。结论高血糖和原发性高血压同样存在RAAS的激活,组织水平干预醛固酮应该成为血糖代谢异常患者的一个治疗目标。
Objective To observe the level of renin-angiotensin-aldosterone (RAA) in patients with hyperglycemia and hypertension and to explore whether RAAS activation is the common pathogenesis of the two. Methods Radioimmunoassay was used to determine plasma RAA level and activity in 106 normal subjects, 112 patients with simple glycometabolism abnormalities, 101 patients with simple essential hypertension and 127 patients with abnormal glucose metabolism and essential hypertension. Results The levels of aldosterone in 3 groups were significantly higher than those in CON group (P <0.01), and the levels of angiotensin Ⅱ in I-IGM group were significantly higher than those in other groups (P <0.01) ), No significant difference in renin activity among the groups. Plasma aldosterone levels and fasting blood glucose, renin, systolic blood pressure, high correlation of angiotensin Ⅱ. Conclusion Hyperglycemia and essential hypertension also exist the activation of RAAS. The intervention of aldosterone at the level of tissue should become a target of treatment in patients with abnormal glucose metabolism.