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患者,女,24岁,已婚,农民。因精神病3年,旧病复发,失眠乱语,行为异常半年于1985年1月5日第二次入我院。既往身体健康,人院体检无异常。心脑电图、CSF、血象等均正常。诊断精神分裂症。因此往用氯丙嗪,氟哌啶醇效果欠佳,故这次入院后予以选用氯氮平治疗,在首次服药以后约10小时,患者即出现面色苍白,精神萎靡昏昏欲睡,不久即小便失禁,大量流涎,陷于昏迷。急测BP 为64/44瞳孔缩小至0.1mm。
Patient, female, 24 years old, married, farmer. Due to mental illness for 3 years, relapse of old disease, insomnia disorders, abnormal behavior for six months in January 5, 1985 the second time into our hospital. Past physical health, hospital medical examination without exception. EEG, CSF, blood and other normal. Diagnosis of schizophrenia. Therefore, the use of chlorpromazine, haloperidol ineffective, so the choice of clozapine treatment after admission, about 10 hours after the first dose, the patient appears pale, apathetic drowsiness, and soon Urinary incontinence, a large number of salivation, in a coma. Urgent test BP 64/44 pupil shrink to 0.1mm.