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应用免疫组织化学SP法 ,对正常肝组织、慢性肝炎、肝硬化、癌旁肝硬化和肝细胞癌共 12 1例进行人胎盘型谷胱甘肽S -转移酶 (GST -π)和甲胎蛋白 (AFP)的检测 .结果 :正常肝组织GST -π和AFP均不表达 ;慢性肝炎GST -π阳性率为 2 5% ( 5/ 2 0 ) ,AFP为阴性 ;肝硬化GST -π阳性率为 19% ( 5/2 7) ,AFP为阴性 ;癌旁肝硬化GTP -π阳性率为 52 % ( 14/ 2 7) ,AFP阳性率为 3 3 % ( 9/ 2 7) ;肝细胞癌GST-π阳性率为 61% ( 2 3 / 3 8) ,AFP阳性率为 4 5% ( 17/ 3 8) .提示 :癌旁肝硬化不同于不伴肝癌的肝硬化而更具癌前病变性质 ;GST -π和AFP联合检测有助于预测和早期诊断肝癌
Immunohistochemical SP method was used to detect the expression of human placental glutathione S-transferase (GST-π) and the mature fetus in 121 normal liver tissues, chronic hepatitis, cirrhosis, paracancer cirrhosis and hepatocellular carcinoma (AFP) .Results: GST-π and AFP were not expressed in normal liver tissue. The positive rate of GST-π in chronic hepatitis was 25% (5/20) and AFP was negative. The positive rate of GST-π in cirrhosis 19% (5/2 7), AFP was negative; the positive rate of GTP-π in paracancer cirrhosis was 52% (14/27); the positive rate of AFP was 33% (9/27); hepatocellular carcinoma The positive rate of GST-π was 61% (2 3/38) and the positive rate of AFP was 45% (17/38) .This suggests that paracancer cirrhosis is different from cirrhosis without hepatocellular carcinoma and more precancerous lesions Nature; GST-π and AFP joint detection can help predict and early diagnosis of liver cancer