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目的:观察VEGF-C和Flt-4在胃癌组织及淋巴管的表达,探讨癌细胞淋巴管转移机理。方法:用免疫组化方法检测人胃癌早期和进展期癌细胞和淋巴管VEGF-C和Flt-4的表达情况。结果:在各期胃癌的癌细胞中均见到VEGF-C和Flt-4阳性表达,淋巴管内皮细胞仅见到Flt-4阳性表达;进展期胃癌两种蛋白的表达率和表达强度都高于早期癌。结论:癌细胞VEGF-C和Flt-4的表达与肿瘤进展呈正相关;淋巴管上Flt-4的表达也与胃癌的进展呈正相关。推测VEGF-C可能通过其受体Flt-4诱导胃癌组织淋巴管发生。
Objective: To observe the expression of VEGF-C and Flt-4 in gastric cancer and lymphatic vessels and explore the mechanism of lymphatic metastasis of cancer cells. Methods: The expression of VEGF-C and Flt-4 in cancer cells and lymphatic vessels in early and advanced stage of human gastric cancer was detected by immunohistochemistry. Results: The positive expression of VEGF-C and Flt-4 were observed in all kinds of gastric cancer cells, and only the positive expression of Flt-4 was found in lymphatic endothelial cells. The expression and expression of both proteins in advanced gastric cancer were higher than Early cancer. Conclusion: The expression of VEGF-C and Flt-4 in cancer cells is positively correlated with tumor progression. The expression of Flt-4 in lymphatic vessels is also positively correlated with the progression of gastric cancer. It is speculated that VEGF-C may induce lymphangiogenesis in gastric cancer tissue through its receptor Flt-4.