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长期腹膜透析会引起腹膜血管生成,对腹膜功能有重大的影响。细胞因子的表达变化在血管新生中起重要的调节作用。目前引起腹膜血管新生的机制还不十分清楚,一般认为正常情况下血管生成的诱导剂与抑制剂处于平衡状态,一旦此平衡被打破,诱导剂多于抑制剂,就会激活内皮细胞长出新血管,反之,则抑制内皮细胞生长使血管退化。现就近年来细胞因子与腹膜血管新生的研究进展予以综述。
Long-term peritoneal dialysis can cause peritoneal angiogenesis, have a significant impact on the peritoneal function. Changes in the expression of cytokines play an important regulatory role in angiogenesis. Currently caused by peritoneal vascularization mechanism is not yet very clear, generally considered normal angiogenic inducers and inhibitors in equilibrium, once the balance is broken, the inducer more than the inhibitor, it will activate the endothelial cells grow new Blood vessels, on the other hand, inhibit endothelial cell growth and degenerate blood vessels. Now on the recent research progress of cytokines and peritoneal vascularization are reviewed.