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目的探讨贝那普利联合美托洛尔治疗左室射血分数(LVEF)正常心力衰竭的临床疗效。方法选择吉安市中心人民医院2013年1月—2014年1月收治的LVEF正常心力衰竭患者55例,随机分为观察组25例和对照组30例。对照组给予贝那普利治疗,观察组给予贝那普利联合美托洛尔治疗,比较两组疗效、治疗前后氨基末端脑钠肽原(NT-pro BNP)水平、心功能指标。结果治疗前两组患者血浆NT-pro BNP水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者血浆NT-pro BNP水平低于对照组,差异有统计学意义(P<0.05)。两组治疗前心率(HR)、左室舒张末内径(LVDd)、LVEF及E/Ea比较,差异无统计学意义(P>0.05);治疗后两组患者HR、LVDd、LVEF及E/Ea比较,差异有统计学意义(P<0.05)。观察组总有效率为96.00%,高于对照组的76.67%,差异有统计学意义(P<0.05)。结论贝那普利联合美托洛尔治疗LVEF正常心力衰竭的临床疗效确切,可有效改善患者心功能。
Objective To investigate the clinical efficacy of benazepril combined with metoprolol in the treatment of normal heart failure with left ventricular ejection fraction (LVEF). Methods 55 cases of normal heart failure patients with LVEF admitted from January 2013 to January 2014 in Ji’an Central People’s Hospital were randomly divided into observation group (25 cases) and control group (30 cases). The control group was treated with benazepril. The observation group was treated with benazepril combined with metoprolol. The curative effect was compared between the two groups. The levels of NT-pro BNP and cardiac function before and after treatment were compared. Results There was no significant difference in plasma NT-pro BNP level between the two groups before treatment (P> 0.05). After treatment, the level of plasma NT-pro BNP in the observation group was lower than that in the control group (P < 0.05). There were no significant differences in HR, LVDd, LVEF and E / Ea between the two groups before treatment (P> 0.05). HR, LVDd, LVEF and E / Ea The difference was statistically significant (P <0.05). The total effective rate in observation group was 96.00%, which was higher than that in control group (76.67%), the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of benazepril combined with metoprolol in the treatment of normal heart failure with LVEF is definite and can effectively improve the cardiac function of patients.