乙型肝炎早期诊断一般以临床表现及HBsAg、IgM抗-HBc等生化检验结果为依据。但约有5～10％的急性乙型肝炎患者仅有IgM抗-HBc阳性的生物学标志,却缺乏HBsAg阳性结果。目前,对这种特殊类型的乙型肝炎尚无足够认识。本文就此进行了研究。作者从836例急性乙型肝炎病人中检出39例HBsAg阴性患者,年龄为18～76岁。在这些患者发病前6个月内的既往史中,33例有胃肠外用药史,9例接受过输血,1例曾 Early diagnosis of hepatitis B is generally based on clinical manifestations and biochemical test results such as HBsAg and IgM anti-HBc. However, about 5% to 10% of patients with acute hepatitis B have only IgM anti-HBc positive biological markers, but lack of HBsAg positive results. At present, there is not enough knowledge about this particular type of hepatitis B. This article has carried on the research to this. The authors identified 39 HBsAg-negative patients from 836 acute hepatitis B patients, aged 18-76 years. In the past 6 months prior to the onset of these patients, 33 had a history of parenteral medication, 9 received blood transfusions, and 1 had had