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目的探讨细胞色素Ｐ４５０１Ａ１（ＣＹＰ１Ａ１）ＭｓｐⅠ基因型和异亮氨酸（Ｉｌｅ）－缬氨酸（Ｖａｌ）基因型与肺癌易感性的关系。方法以病例－对照的研究方法，采用ＰＣＲ－ＲＦＬＰ和ＡＳＡ技术检测５９例原发性肺癌、５９名住院对照和７３名健康对照ＣＹＰ１Ａ１ＭｓｐⅠ和Ｉｌｅ－Ｖａｌ基因型。结果ＭｓｐⅠ纯合突变型Ｃ和缬氨酸纯合型（Ｖａｌ／Ｖａｌ）在病例组各占２５．４％和１１．９％，对照组中平均各占１６．５％和７．０％，相比较无显著性差异（Ｐ＞０．０５）。未发现吸烟与ＭｓｐⅠＣ型和Ｖａｌ／Ｖａｌ型有关。在非吸烟组ＭｓｐⅠＣ型者患肺癌的危险性（ＯＲ）是其他基因型的２．４３～２．９１倍（９５％可信限：１．１２～５．２５和１．１３～７．５２），ＭｓｐⅠ杂合型Ｂ在健康对照和病例组分别占６１．６％和３７．３％（Ｐ＜０．０１），ＯＲ为０．３７（９５％可信限：０．１７～０．８０）。Ｉｌｅ／Ｖａｌ杂合型在医院对照组占８１．４％，病例组为５５．９％，差异极显著（Ｐ＜０．０１），ＯＲ为０．２９（９５％可信限：０．１２～０．７２）。有家族肿瘤史的肺癌Ｖａｌ／Ｖａｌ型占５０％（３／６），显著高于对照组（０／１８），Ｐ＜０．０１。结论ＭｓｐⅠＣ型?
Objective To investigate the relationship between cytochrome P4501A1 (CYP1A1) MspI genotype, isoleucine (Ile)-valine (Val) genotype and susceptibility to lung cancer. METHODS: A case-control study was performed using PCR-RFLP and ASA techniques to detect the CYP1A1 MspI and Ile-Val genotypes in 59 patients with primary lung cancer, 59 hospital controls, and 73 healthy controls. Results MspI homozygous mutant C and valine homozygous (Val/Val) accounted for 25.4% and 11.9% in the case group and 16.5% and 7.0% in the control group, respectively. There was no significant difference (P>0.05). No smoking was found to be associated with MspIC type and Val/Val type. In the non-smoking group, the risk of lung cancer was 2.43 to 2.91 times higher than that of other genotypes (95% confidence limits: 1.12 to 5.25 and 1.13 to 7.52). ), MspI heterozygous B accounted for 61.6% and 37.3% in healthy controls and case groups, respectively (P < 0.01), OR was 0.37 (95% confidence limit: 0.17 ~ 0. 80). Ile/Val heterozygous type accounted for 81.4% in the hospital control group and 55.9% in the case group, the difference was extremely significant (P<0.01), and the OR was 0.29 (95% confidence limit: 0.12 ~ 0.72). The Val/Val type of lung cancer with a family history of cancer accounted for 50% (3/6), which was significantly higher than that of the control group (0/18), P<0.01. Conclusion MspIC type?