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目的：探讨丙戊酸钠(VPA)治疗癫痫儿童药物剂量与血药浓度之间的关系以及在血药浓度监测下调节给药剂量的临床意义。方法：选择单用VPA治疗的癫痫患儿90例，在服药5~7个半衰期(t1/2=5~20h)后，于晨空腹采静脉血2ml，用荧光偏振免疫分析仪(TDX美国Abbott公司)测定。结果：服药剂量为每日10~30mg/kg时，血药浓度与剂量呈正相关(r=0.56，P<0.05)，各体重组间的血药浓度与剂量的回归直线不重叠(F=12.1，P<0.01)：体重<10kg组呈低度相关(r=0.30)，体重>30kg组呈中度相关(r=0.56)。结论：在血药浓度监测下调整个体的给药剂量，可以取得较好的临床疗效。
Objective: To investigate the relationship between drug dosage and plasma concentration of VPA in children with epilepsy and the clinical significance of adjusting the dose of drug in plasma concentration monitoring. Methods: Ninety children with epilepsy treated with VPA alone were enrolled in this study. Fasting venous blood samples were collected in fasting morning (2ml) at 5 to 7 half-lives (t1 / 2 = 5 ~ 20h). Fluorescence polarization immunoassay (TDX Abbott Company). Results: When the dose was 10 ~ 30mg / kg daily, the plasma concentration was positively correlated with the dose (r = 0.56, P <0.05). The linear regression of plasma concentration and dose did not overlap (F = 12.1 , P <0.01). There was a low correlation between body weight <10 kg (r = 0.30) and body weight> 30 kg (r = 0.56). Conclusion: Adjusting the dose of the individual under the monitoring of plasma concentration can achieve better clinical efficacy.