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目的分析原发性鼻腔非霍奇金淋巴瘤的临床特点,以进一步提高诊治率。方法对24例原发性鼻腔淋巴瘤患者的临床资料进行回顾性研究,分析其临床表现、诊断及误诊原因。结果患者早期临床症状不典型,鼻镜、CT检查缺乏特异性,误诊9例(37.5%),所有病例最后经病理及免疫组化检查确诊。21例行免疫组化检查显示,T细胞淋巴瘤12例(57.2%),B细胞淋巴瘤5例(23.8%),T/NK细胞淋巴瘤4例(19.0%)。22例采用化放疗治疗后,完全缓解(CR)16例(72.7%),部分缓解(PR)6例(27.3%),随访期间死亡6例。结论鼻腔恶性淋巴瘤主要为T细胞型淋巴瘤。由于其临床表现、鼻腔鼻窦内镜及CT检查具有非特异性,误诊率较高。
Objective To analyze the clinical features of primary nasal non-Hodgkin’s lymphoma in order to further improve the diagnosis and treatment rate. Methods The clinical data of 24 patients with primary nasal lymphoma were retrospectively analyzed, and their clinical manifestations, diagnosis and misdiagnosis were analyzed. Results The early clinical symptoms of patients were not typical, the specificity of nose and CT examination was poor, and 9 cases were misdiagnosed (37.5%). All the cases were diagnosed by pathology and immunohistochemistry finally. 21 routine immunohistochemical examination showed that T cell lymphoma in 12 cases (57.2%), B cell lymphoma in 5 cases (23.8%), T / NK cell lymphoma in 4 cases (19.0%). Twenty-two patients achieved complete remission (CR) in 16 patients (72.7%), partial response (PR) in 6 patients (27.3%) and 6 patients died during follow-up after treatment with chemoradiotherapy. Conclusions Nasal malignant lymphoma is mainly T cell lymphoma. Because of its clinical manifestations, nasal sinus endoscopy and CT has a non-specific, misdiagnosis rate.