1 病例资料女,39岁,已婚。因颜面、双上臂及双小腿皮肤肿硬9个月入院。9个月前无明显诱因出现颜面、双上肢、双小腿以下皮肤肿胀,双小腿皮肤发红,活动不便,伴乏力、记忆力减退、嗜睡、畏寒、皮肤变黄、脱发,逐渐加重,诊断肢端硬化型硬皮病,收住皮肤科。既往第一胎流产,第二胎顺产,1年前因其夫突然去世而出现停 1 Case Information Female, 39 years old, married. Due to face, double upper arm and double leg skin swelling hard 9 months admission. 9 months ago there is no obvious incentive to appear face, upper extremity, swelling of the skin below the lower leg, double calf skin redness, activity inconvenience, with fatigue, memory loss, lethargy, chills, yellowing, hair loss, gradual increase in diagnosis of limbs Sclerotic scleroderma, receiving dermatology. In the past the first abortion, the second child, a year ago because of her husband suddenly died