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本文应用扫描电镜检查了有不同吸烟史的人体手术切除支气管及离体培养并加卷烟中性焦油的金黄地鼠气管环。结果看到了吸烟人体支气管上皮表层纤毛脱落,下面的无纤毛细胞增生及鳞状化生。有的并可见纤毛脱落的上皮局部表面形成圆形洞穴。动物的气管在离体培养并加中性卷烟焦油作用7日即出现纤毛脱落,无纤毛细胞增生及鳞状化生现象与化学致癌物质苯胼芘的作用相同。
In this paper, scanning electron microscopy was used to examine the trachea rings of golden hamsters with different smoking history in humans who had undergone surgical excision of the bronchus and cultured in vitro and added cigarettes with neutral tar. The results showed that the cilia in the bronchial epithelial surface of the smoker were exfoliated, and the following non-ciliated cell proliferation and squamous metaplasia. Some of the epithelial surfaces with visible cilia can be seen to form round caverns. The trachea of the animals was exfoliated in vitro and added with neutral cigarette tar on the 7th day. Ciliated exfoliation occurred and the non-ciliated cell proliferation and squamous metaplasia were the same as those of the chemical carcinogen phenylhydrazone.