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目的探讨抵抗素在2型糖尿病中的变化及其与有关指标的相互关系。方法选择70例2型糖尿病患者以及15名对照者,2型糖尿病患者按体重指数(BMI)分组,应用酶联免疫吸附试验(ELISA)检测外周血中的抵抗素浓度,氧化酶法测定血糖,放射免疫法测定胰岛素。结果糖尿病组抵抗素含量平均为(23.06±9.34)μg/L,显著高于对照组(P<0.01);抵抗素与BMI呈正相关(P<0.01),与葡萄糖曲线下面积(GAUC)呈正相关(P<0.01),与体脂分布呈正相关(P<0.01),与胰岛素抵抗指数呈负相关(P<0.01),与胰岛素曲线下面积无相关关系(P>0.05)。并经逐步多元回归得出回归方程:抵抗素=-15.869+0.339×GAUC+0.790×BMI。结论糖尿病患者体内有较高浓度的抵抗素,抵抗素与GAUC有密切关系。
Objective To investigate the changes of resistin in type 2 diabetes mellitus (T2DM) and its relationship with related indicators. Methods 70 patients with type 2 diabetes mellitus and 15 controls were selected. Patients with type 2 diabetes were divided into two groups according to body mass index (BMI). The levels of resistin in peripheral blood were detected by enzyme-linked immunosorbent assay (ELISA) Radioimmunoassay for the determination of insulin. Results The average level of resistin in diabetic group was (23.06 ± 9.34) μg / L, which was significantly higher than that in control group (P <0.01). There was a positive correlation between resistin and BMI (P <0.01) (P <0.01), and was positively correlated with body fat distribution (P <0.01), negatively correlated with insulin resistance index (P <0.01), and had no correlation with the area under insulin curve (P> 0.05). Regression equation was obtained by stepwise multiple regression: resistin = -15.869 + 0.339 × GAUC + 0.790 × BMI. Conclusion There is a higher concentration of resistin in diabetic patients, and resistin is closely related to GAUC.