通常认为在gp_(120)-CD4的反应中,gp_(120)上的特定位点与CD4分子上的特定位点CDR_2样区相互作用,CDR_2样区在病毒结合和细胞融合中是必需的.CDR_3样区参与了gp_(120)-CD4的反应,但CDR_3样区的功能尚不清楚.在实验中用分别针对CDR_2样区、CDR_3样区的单抗OKT4A、13B8-2及对照单抗OKT4作对照研究,发现13B8-2与OKT4A作用相似,均阻断了sgp_(120)-sCD4 It is generally believed that in the gp120-CD4 response, a specific site on gp120 interacts with a specific site CDR2-like region on the CD4 molecule, which is required for viral binding and cell fusion. The CDR3-like region is involved in the reaction of gp120-CD4, but the function of the CDR3-like region is unclear.In the experiments, the monoclonal antibodies OKT4A, 13B8-2 and the CDR3-specific monoclonal antibodies OKT4 As a control study, found that 13B8-2 and OKT4A similar role, were blocked sgp_ (120) -sCD4