目的评价国产Amplatzer封堵器治疗先天性心脏病室间隔缺损(VSD)的临床疗效及其应用前景。方法选择22例VSD患者(男12例,女10例,年龄7~40岁),其中伴膜部瘤者有1例,VSD直径(3.5~8.9mm)。在经胸超声心动图(TTE)及X线影像指导下,经鞘管应用合适的国产Amplatzer封堵伞进行封堵,术后应用超声心动图观察疗效。结果在对患者1年的随访中,除1例有少量残余分流外,余未见残余分流,瓣膜反流程度无加重。结论应用国产Amplatzer封堵器介入治疗VSD操作简单,成功率高,疗效可靠、安全,近期临床疗效好。 Objective To evaluate the clinical efficacy and prospects of domestic Amplatzer occluder in the treatment of congenital heart disease ventricular septal defect (VSD). Methods Twenty-two patients with VSD (12 males and 10 females, aged 7 to 40 years) were selected. Among them, 1 had companion tumor and VSD diameter (3.5 ~ 8.9 mm). Under the guidance of transthoracic echocardiography (TTE) and X-ray, the appropriate domestic Amplatzer occluder was occluded by sheath and the echocardiogram was used to observe the effect. Results In 1-year follow-up of patients, except for a small residual shunt, I did not see residual shunt, valvular regurgitation did not aggravate. Conclusion The application of domestic Amplatzer occluder interventional therapy VSD is simple, high success rate, reliable, safe, and short-term clinical efficacy.