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以DCC 7点Scatchard作图法测定23例胃癌组织中的ER含量,发现6例ER阳性(26.1％),其中男病人16例有4例阳性,女病人7例有2例阳性,ER水平22.5-117.3fmole/mg蛋白/ml胞液,ER阳性的病例皆属低分化细胞型肿瘤。经实验证明本组胃癌测到的ER与乳腺癌的ER的生物学特异性一致。作者从胎儿胃及其他有些脏器中测到ER的存在,更进一步支持非靶器官肿瘤中存在ER是胎儿产生激素基因重现的推论。至于胃癌中ER阳性是否有指导治疗意义,尚有待进一步研究。
DCC 7 point Scatchard plot method was used to determine the ER content in 23 cases of gastric cancer. 6 cases were found to be ER positive (26.1%), among which 16 cases were positive in male patients, 2 cases were positive in 7 cases in female patients, and ER level was 22.5. The ER-positive cases of -117.3 fmole/mg protein/ml cytoplasm are all poorly differentiated cell type tumors. The experiments showed that the biological specificity of ER detected in gastric cancer in this group was consistent with that of breast cancer. The authors detected the presence of ER from the fetal stomach and other organs, further supporting the existence of ER in non-target organ tumors as a corollary of the fetal hormone gene reappearance. As for whether ER positive in gastric cancer has guiding treatment significance, it needs further study.