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目的探讨不同老年人群胰岛素敏感性与前列腺体积的关系。方法该院收治的糖尿病和(或)前列腺增生住院患者117例根据血糖水平分为正常糖耐量组(N组)、空腹血糖过高组(IFG组)、糖耐量减低组(IGT组)和2型糖尿病组(T2DM组)。检测人体测量学参数、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),行OGTT和胰岛素释放实验(IRT),并计算胰岛素敏感指数(HOMA-IR)。由超声医师行经腹超声检查,计算前列腺体积。Pearson相关分析法分析HOMA-IR与前列腺体积的关系。结果 IFG组、IGT组、T2DM组HOMA-IR及前列腺体积均高于N组(P<0.01)。T2DM组HOMA-IR及前列腺体积均高于IFG组、IGT组(P<0.01)。HOMA-IR与前列腺体积呈正相关(r=0.527,P<0.01)。结论前列腺体积在糖耐量异常人群中是升高的,且其与胰岛素抵抗呈正相关。胰岛素抵抗越重,前列腺体积越大。
Objective To investigate the relationship between insulin sensitivity and prostate volume in different elderly population. Methods One hundred and seventy-seven inpatients with diabetes and / or benign prostatic hyperplasia were divided into normal glucose tolerance group (N group), fasting hyperglycemia group (IFG group), impaired glucose tolerance group (IGT group) and 2 Diabetes group (T2DM group). The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured, and OGTT and insulin release test (IRT) , And calculate insulin sensitivity index (HOMA-IR). The sonographer performed abdominal ultrasonography to calculate the prostate volume. Pearson correlation analysis of HOMA-IR and prostate volume relationship. Results HOMA-IR and prostate volume in IFG group, IGT group and T2DM group were higher than those in N group (P <0.01). HOMA-IR and prostate volume in T2DM group were higher than those in IFG group and IGT group (P <0.01). HOMA-IR was positively correlated with prostate volume (r = 0.527, P <0.01). Conclusions Prostate volume is elevated in people with impaired glucose tolerance and positively correlated with insulin resistance. The more severe insulin resistance, the greater the prostate volume.