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一、乙肝病毒感染的促癌作用和直接致癌作用乙型肝炎病毒(HBV)携带者比对照组的肝癌发生率约高100倍。全球约有2亿,日本约有300万HBV携带者,其中10%发生肝炎和肝硬变,中年以后多有发生肝癌者。慢性肝炎和肝硬变持续或断续发生细胞崩解破坏,继而进行增殖。这种状态对在不同环境中,甚或在体内发生的癌原因素具有辅助的致癌作用,即辅起动子(CO-initiater)作用,或促进子(promoter)作用。进入80年代以来,发现肝癌宿主细胞DNA中多整合有HBV·DNA,这种整合可能具有直接致癌作用,即同其他癌原因子一样具有起动作用和促进作用。法国学者Brechot等指出,HBV标志阴性肝癌巾均可见这种整合,故引起了世人的瞩目。
First, the role of promoting the cancer and direct carcinogenic effects of hepatitis B virus infection Hepatitis B virus (HBV) carriers than the control group, the incidence of liver cancer is about 100 times higher. There are about 200 million people in the world and about 3 million HBV carriers in Japan, of which 10% have hepatitis and cirrhosis, and many have liver cancer after middle age. Chronic hepatitis and cirrhosis continuous or intermittent cell disruption, followed by proliferation. This state has an auxiliary oncogenic effect, namely, a CO-initiater effect or a promoter effect on cancer factors occurring in different environments or even in vivo. Since the 1980s, HBV DNA has been found in the DNA of hepatocarcinoma host cells. This integration may have a direct carcinogenic effect, that is to say, it has the same priming effect as other cancer factors. French scholar Brechot and others pointed out that HBV-negative liver cancer towels are visible in this integration, it attracted the world’s attention.