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拉米夫定是目前应用较广的核苷类似抗病毒药物 ,能有效地抑制乙型肝炎病毒 (ＨＢＶ)的复制。目前在国内主要用于慢性乙型肝炎患者抗ＨＢＶ治疗。在治疗过程中 ,ＨＢＶ可发生聚合酶的变异而产生对拉米夫定的耐药。为了研究ＨＢＶ聚合酶变异的分布及临床意义 ,笔者观察了在拉米夫
Lamivudine is currently a widely used nucleoside analogue antiviral drug, which can effectively inhibit the replication of hepatitis B virus (HBV). Currently in the country mainly for anti-HBV treatment in patients with chronic hepatitis B. In the course of treatment, HBV can occur polymerase mutation and produce resistance to lamivudine. In order to study the distribution of HBV polymerase mutations and clinical significance, the author observed in Lamiv